For nearly 60 years, Moore’s Law has exponentially increased our ability to compute and has transformed the way we live. Today, we live in a world in which nearly every aspect of our lives is touched by technology, including technology itself - which finds itself in a virtuous cycle of increasing demand driven by increasing capability. As graphics and AI applications create new and taxing compute workloads, storage needs and power-hungry data transfer rates, advancing Moore’s Law has become more relevant than ever. The semiconductor industry faces many grand challenges, from transistor to interconnects, to system-level architectures, but there is a path forward. The continuing growth in manufacturing complexity increases both cost and security risk, requiring judicious decisions on where to focus and, just as importantly, where not to focus, to ensure the continuation of Moore’s Law economics.