The Semiconductor Sector is facing an unprecedented set of challenges in the next few years as new computing capabilities, particularly in AI, are driving demand for computing capabilities beyond anything previously imagined. The impact of power demands to drive those capabilities, and the sustainability of the overall production and deployment of computing is enormously challenging for the sector. In this presentation, we discuss the complex interlocking challenges which are arising and suggest opportunities to address these challenges through innovation in the underlying technologies that underpin future computing approaches.