Role of Artificial Intelligence (AI) is seeing a great interest in multiple end markets - Automotive, Home and Industrial IOT, Mobile Devices, Communications and Data centers to name few. The value proposition is further strengthened in HV semiconductor manufacturing to further enhance the speed-quality- cost balance by realization of enormous data analytics, efficient tool management, factory operations and materials innovation in this dynamic foundry landscape while minimizing the total cost of ownership. This presentation will explore the potential opportunities of AI and Machine learning supporting the materials, equipment and metrology efficiencies while minimizing the variations in foundry HVM environment.